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Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.
Harris, Valerie M; Sharma, Rohan; Cavett, Joshua; Kurien, Biji T; Liu, Ke; Koelsch, Kristi A; Rasmussen, Astrid; Radfar, Lida; Lewis, David; Stone, Donald U; Kaufman, C Erick; Li, Shibo; Segal, Barbara; Wallace, Daniel J; Weisman, Michael H; Venuturupalli, Swamy; Kelly, Jennifer A; Alarcon-Riquelme, Marta E; Pons-Estel, Bernardo; Jonsson, Roland; Lu, Xianglan; Gottenberg, Jacques-Eric; Anaya, Juan-Manuel; Cunninghame-Graham, Deborah S; Huang, Andrew J W; Brennan, Michael T; Hughes, Pamela; Alevizos, Ilias; Miceli-Richard, Corinne; Keystone, Edward C; Bykerk, Vivian P; Hirschfield, Gideon; Xie, Gang; Siminovitch, Katherine A; Ng, Wan-Fai; Nordmark, Gunnel; Bucher, Sara Magnusson; Eriksson, Per; Omdal, Roald; Rhodus, Nelson L; Rischmueller, Maureen; Rohrer, Michael; Wahren-Herlenius, Marie; Witte, Torsten; Mariette, Xavier; Lessard, Christopher J; Harley, John B; Sivils, Kathy L; Scofield, R Hal.
Afiliação
  • Harris VM; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Sharma R; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
  • Cavett J; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Kurien BT; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City
  • Liu K; Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
  • Koelsch KA; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City
  • Rasmussen A; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Radfar L; Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
  • Lewis D; Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
  • Stone DU; Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
  • Kaufman CE; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Li S; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  • Segal B; Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Wallace DJ; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Weisman MH; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Venuturupalli S; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Kelly JA; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Alarcon-Riquelme ME; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain.
  • Pons-Estel B; Sanatorio Parque, Rosario, Argentina.
  • Jonsson R; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway; Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway.
  • Lu X; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  • Gottenberg JE; Strasbourg University, Strasbourg, France.
  • Anaya JM; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
  • Cunninghame-Graham DS; Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK.
  • Huang AJW; Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.
  • Brennan MT; Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.
  • Hughes P; Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.
  • Alevizos I; Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA.
  • Miceli-Richard C; Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.
  • Keystone EC; Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
  • Bykerk VP; Hospital for Special Surgery, New York, USA.
  • Hirschfield G; NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.
  • Xie G; Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Ng WF; Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.
  • Nordmark G; Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Bucher SM; Department of Rheumatology, Örebro University Hospital, Örebro, Sweden.
  • Eriksson P; Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.
  • Omdal R; Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
  • Rhodus NL; Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.
  • Rischmueller M; Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
  • Rohrer M; Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.
  • Wahren-Herlenius M; Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Witte T; Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.
  • Mariette X; Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.
  • Lessard CJ; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Harley JB; Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.
  • Sivils KL; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Scofield RH; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health S
Clin Immunol ; 168: 25-29, 2016 07.
Article em En | MEDLINE | ID: mdl-27109640
ABSTRACT
Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Síndrome de Sjogren / Síndrome de Klinefelter / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials Limite: Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Síndrome de Sjogren / Síndrome de Klinefelter / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials Limite: Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article