Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents.

Fang, Xue-Jie; Jeyakkumar, Ponmani; Avula, Srinivasa Rao; Zhou, Qian; Zhou, Cheng-He

Fang, Xue-Jie; Jeyakkumar, Ponmani; Avula, Srinivasa Rao; Zhou, Qian; Zhou, Cheng-He.

Afiliação

Fang XJ; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Jeyakkumar P; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Avula SR; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Zhou Q; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Zhou CH; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: zhouch@swu.edu.cn.

Bioorg Med Chem Lett ; 26(11): 2584-8, 2016 06 01.

Article em En | MEDLINE | ID: mdl-27117429

Assuntos

Antibacterianos/farmacologia; Antifúngicos/farmacologia; Bactérias/efeitos dos fármacos; Benzimidazóis/farmacologia; Desenho de Fármacos; Fluoruracila/farmacologia; Fungos/efeitos dos fármacos; Antibacterianos/síntese química; Antibacterianos/química; Antifúngicos/síntese química; Antifúngicos/química; Benzimidazóis/síntese química; Benzimidazóis/química; Relação Dose-Resposta a Droga; Fluoruracila/química; Testes de Sensibilidade Microbiana; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

5-Fluorouracil; Antibacterial; Antifungal; Benzimidazole; DNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bactérias / Benzimidazóis / Desenho de Fármacos / Fluoruracila / Fungos / Antibacterianos / Antifúngicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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