Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway.
Org Lett
; 18(9): 2256-9, 2016 05 06.
Article
em En
| MEDLINE
| ID: mdl-27120128
ABSTRACT
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Rifabutina
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Staphylococcus aureus Resistente à Meticilina
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Policetídeos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article