Perioperative time course of matrix metalloproteinase-9 (MMP-9), its tissue inhibitor TIMP-1 & S100B protein in carotid surgery.
Indian J Med Res
; 143(2): 220-6, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-27121520
ABSTRACT
BACKGROUND & OBJECTIVES:
Ischaemic stroke is a life burdening disease for which carotid endarterectomy (CEA) is considered a gold standard intervention. Pro-inflammatory markers like matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) and S-100 Beta (S100B) may have a role in the early inflammation and cognitive decline following CEA. This study was aimed to describe the perioperative time courses and correlations between of MMP-9, TIMP-1 and S100B following CEA.METHODS:
Fifty four patients scheduled for CEA were enrolled. Blood samples were collected at four time points, T 1 preoperative, T 2 60 min after cross-clamp release, T 3 first postoperative morning, T 4 third postoperative morning. Twenty atherosclerotic patients were included as controls. Plasma MMP-9, TIMP-1 and S100B levels were estimated by ELISA.RESULTS:
TIMP-1 was decreased significantly in the CEA group (P<0.01). Plasma MMP-9 was elevated and remained elevated from T 1-4 in the CEA group (P<0.05) with a marked elevation in T 3 compared to T 1 (P<0.05). MMP-9/TIMP-1 was elevated in the CEA group and increased further by T 2 and T 3 (P<0.05). S100B was elevated on T 2 and decreased on T 3-4 compared to T 1 . INTERPRETATION &CONCLUSIONS:
Our study provides information on the dynamic changes of MMP-9-TIMP-1 system and S100B in the perioperative period. Preoperative reduction of TIMP-1 might be predictive for shunt requirement but future studies are required for verification.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endarterectomia das Carótidas
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Inibidor Tecidual de Metaloproteinase-1
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Acidente Vascular Cerebral
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Metaloproteinase 9 da Matriz
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Subunidade beta da Proteína Ligante de Cálcio S100
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article