Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.

Diehl, Carl; Akke, Mikael; Bekker-Jensen, Simon; Mailand, Niels; Streicher, Werner; Wikström, Mats

Diehl, Carl; Akke, Mikael; Bekker-Jensen, Simon; Mailand, Niels; Streicher, Werner; Wikström, Mats.

Afiliação

Diehl C; From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark,; SARomics Biostructures, SE-22363 Lund, Sweden.
Akke M; Department of Biophysical Chemistry, Center for Molecular Protein Science, Lund University, SE-22100 Lund, Sweden.
Bekker-Jensen S; From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Mailand N; From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Streicher W; From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark,; Novozymes A/S, DK-2880 Bagsvaerd, Denmark, and.
Wikström M; From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark,; Amgen Inc., Thousand Oaks, California 91320. Electronic address: mats.wikstrom@amgen.com.

J Biol Chem ; 291(24): 12658-12672, 2016 Jun 10.

Article em En | MEDLINE | ID: mdl-27129204

Assuntos

Proteína de Ligação a CREB/química; Epitopos/química; Domínios Proteicos; Proteína SUMO-1/química; Motivos de Aminoácidos; Sequência de Aminoácidos; Sítios de Ligação/genética; Proteína de Ligação a CREB/genética; Proteína de Ligação a CREB/metabolismo; Calorimetria/métodos; Epitopos/genética; Epitopos/metabolismo; Humanos; Cinética; Ligantes; Espectroscopia de Ressonância Magnética; Modelos Moleculares; Mutação; Ligação Proteica; Proteína SUMO-1/genética; Proteína SUMO-1/metabolismo; Termodinâmica

Palavras-chave

SUMO-interacting motif (SIM); biophysics; nuclear magnetic resonance (NMR); protein dynamics; protein structure; protein-protein interaction; structural biology; structural model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína SUMO-1 / Proteína de Ligação a CREB / Domínios Proteicos / Epitopos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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