Drug Utilization and Inappropriate Prescribing in Centenarians.
J Am Geriatr Soc
; 64(5): 1079-84, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27130965
ABSTRACT
OBJECTIVES:
To use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100.DESIGN:
Population-based cohort study.SETTING:
Primary care database in the United Kingdom, 1990 to 2013.PARTICIPANTS:
Individuals reaching the age of 100 between 1990 and 2013 (N = 11,084; n = 8,982 women, n = 2,102 men). MEASUREMENTS Main drug classes prescribed and potentially inappropriate prescribing according to the 2012 American Geriatrics Society Beers Criteria.RESULTS:
At the age of 100, 73% of individuals (79% of women, 54% of men) had received one or more prescription drugs, with a median of 7 (interquartile range 0-12) prescription items. The most frequently prescribed drug classes were cardiovascular (53%), central nervous system (CNS) (53%), and gastrointestinal (47%). Overall, 32% of participants (28% of men, 32% of women) who received drug prescriptions may have received one or more potentially inappropriate prescriptions, with temazepam and amitriptyline being the most frequent. CNS prescriptions were potentially inappropriate in 23% of individuals, and anticholinergic prescriptions were potentially inappropriate in 18% of individuals.CONCLUSION:
The majority of centenarians are prescribed one or more drug therapies, and the prescription may be inappropriate for up to one-third of these individuals. Research using EHRs offers opportunities to understand prescribing trends and improve pharmacological care of the oldest adults.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Uso de Medicamentos
/
Prescrição Inadequada
Tipo de estudo:
Observational_studies
Limite:
Aged80
/
Female
/
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article