A Valuable Upgrade to the Portfolio of Cycloaddition Reactions.

ABSTRACT

Knitting Recently Antonchick and Manna described a unique annulation that knits together three acetophenones to construct cyclopropanes. The cascade is mediated by organocopper and free radical species, and amounts to the first known [1+1+1] cyclotrimerization. It works well for ketones having electron-deficient or electron-rich substituents in their aryl rings. DTBP=di-tert-butylperoxide.