Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers.
Endocr Res
; 42(1): 42-48, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27144920
ABSTRACT
BACKGROUND:
Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level.OBJECTIVES:
This study compared the reliability of the STg/TSH ratio and STg measurement in predicting the success of RIT.METHODS:
Sixty-three DTC patients submitted to TT were assessed retrospectively to compare the ability of STg level and the STg/TSH ratio to predict successful RIT.RESULTS:
In this study 48 (76.2%) patients had successful RIT. The successful and unsuccessful groups received different 131I doses and had different STg levels and STg/TSH ratios. The STg and STg/TSH ratio cutoff values that predicted successful RIT were 4.41 ng/mL (sensitivity of 86.7% and specificity of 77%) and 0.093 (sensitivity of 80% and specificity of 79.2%), respectively. Age, STg level, STg/TSH ratio, and 131I dose were associated with successful RIT, but after multivariate analysis only STg remained associated (p < 0.05).CONCLUSION:
In conclusion, our data suggest that the STg/TSH ratio and measurement of STg are equally reliable in predicting successful RIT in DTC patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Tireoglobulina
/
Neoplasias da Glândula Tireoide
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Tireotropina
/
Carcinoma
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Avaliação de Resultados em Cuidados de Saúde
/
Radioisótopos do Iodo
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article