The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

Schilderink, Ronald; Verseijden, Caroline; Seppen, Jurgen; Muncan, Vanesa; van den Brink, Gijs R; Lambers, Tim T; van Tol, Eric A; de Jonge, Wouter J

Schilderink, Ronald; Verseijden, Caroline; Seppen, Jurgen; Muncan, Vanesa; van den Brink, Gijs R; Lambers, Tim T; van Tol, Eric A; de Jonge, Wouter J.

Afiliação

Schilderink R; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands;
Verseijden C; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands;
Seppen J; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands;
Muncan V; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands;
van den Brink GR; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands; and.
Lambers TT; Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.
van Tol EA; Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.
de Jonge WJ; Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands; and w.j.dejonge@amc.nl.

Am J Physiol Gastrointest Liver Physiol ; 310(11): G1138-46, 2016 06 01.

Article em En | MEDLINE | ID: mdl-27151945

Assuntos

Butiratos/farmacologia; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/metabolismo; Mucosa Intestinal/efeitos dos fármacos; Tretinoína/metabolismo; Aldeído Oxirredutases/genética; Aldeído Oxirredutases/metabolismo; Animais; Células CACO-2; Células Cultivadas; Humanos; Mucosa Intestinal/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Proteínas dos Microfilamentos/genética; Proteínas dos Microfilamentos/metabolismo; Mucina-2/genética; Mucina-2/metabolismo

Palavras-chave

butyrate; epithelial cells; immune tolerance; retinoic acid; short-chain fatty acids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Butiratos / Inibidores de Histona Desacetilases / Histona Desacetilases / Mucosa Intestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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