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High-performance web services for querying gene and variant annotation.
Xin, Jiwen; Mark, Adam; Afrasiabi, Cyrus; Tsueng, Ginger; Juchler, Moritz; Gopal, Nikhil; Stupp, Gregory S; Putman, Timothy E; Ainscough, Benjamin J; Griffith, Obi L; Torkamani, Ali; Whetzel, Patricia L; Mungall, Christopher J; Mooney, Sean D; Su, Andrew I; Wu, Chunlei.
Afiliação
  • Xin J; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Mark A; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Afrasiabi C; Current address: Avera Cancer Institute, 11099 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Tsueng G; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Juchler M; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Gopal N; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA.
  • Stupp GS; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA.
  • Putman TE; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Ainscough BJ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Griffith OL; McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave, St. Louis, MO, 63108, USA.
  • Torkamani A; McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave, St. Louis, MO, 63108, USA.
  • Whetzel PL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Mungall CJ; The Scripps Translational Science Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
  • Mooney SD; Center for Research in Biological Systems, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Su AI; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA.
  • Wu C; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA.
Genome Biol ; 17(1): 91, 2016 05 06.
Article em En | MEDLINE | ID: mdl-27154141
Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.info and http://myvariant.info . Both are offered free of charge to the research community.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Software / Análise de Sequência de DNA / Anotação de Sequência Molecular Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Software / Análise de Sequência de DNA / Anotação de Sequência Molecular Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article