Sequence Variations in the Non-Coding Sequence of CTX Phages in Vibrio cholerae.
J Microbiol Biotechnol
; 26(8): 1473-80, 2016 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-27160575
ABSTRACT
This study focused on the variations in the non-coding sequences between ctxB and rstR of various CTX phages. The non-coding sequences of CTX-1 and CTX-cla are phage type-specific. The length of the non-coding region of CTX-1 and CTX-cla is 601 and 730 nucleotides, respectively. The non-coding sequence of CTX phage could be divided into three regions. There is a phage type-specific Variable region between two homologous Common regions (Common regions 1 and 2). The non-coding sequence of RS1 element is similar to CTX-1 except that Common region 1 is replaced by a short RS1-specific sequence. The non-coding sequences of CTX-2 and CTX-cla are homologous, indicating the non-coding sequence of CTX-2 is derived from CTX-cla. The non-coding region of CTX-O139 is similar to CTX-cla and CTX-2; however, it contains an extra phage type-specific sequence between Common region 2 and rstR. The variations in the non-coding sequences of CTX phages might be associated with the difference in the replication efficiency and the directionality in the integration into the V. cholerae chromosome.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bacteriófagos
/
Variação Genética
/
Vibrio cholerae
/
Proteínas Virais
/
Toxina da Cólera
/
RNA não Traduzido
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article