Concise synthesis of calystegines B2 and B3via intramolecular Nozaki-Hiyama-Kishi reaction.
Org Biomol Chem
; 14(21): 4885-96, 2016 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-27161660
ABSTRACT
The key step in the concise syntheses of calystegine B2 and its C-2 epimer calystegine B3 was the construction of cycloheptanone 8via an intramolecular Nozaki-Hiyama-Kishi (NHK) reaction of 9, an aldehyde containing a Z-vinyl iodide. Vinyl iodide 9 was obtained by the Stork olefination of aldehyde 10, derived from carbohydrate starting materials. Calystegines B2 (3) and B3 (4) were synthesized from d-xylose and l-arabinose derivatives respectively in 11 steps in excellent overall yields (27% and 19%).
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1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Solanáceas
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Inibidores Enzimáticos
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Nortropanos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article