Proton Pump Inhibitors Accelerate Endothelial Senescence.
Circ Res
; 118(12): e36-42, 2016 06 10.
Article
em En
| MEDLINE
| ID: mdl-27166251
ABSTRACT
RATIONALE Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. OBJECTIVE:
To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. METHODS ANDRESULTS:
Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.CONCLUSIONS:
Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Senescência Celular
/
Células Endoteliais
/
Inibidores da Bomba de Prótons
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article