Copper-Catalyzed Carbonylative Coupling of Cycloalkanes and Amides.
Angew Chem Int Ed Engl
; 55(25): 7227-30, 2016 06 13.
Article
em En
| MEDLINE
| ID: mdl-27167881
ABSTRACT
Carbonylation reactions are a most powerful method for the synthesis of carbonyl-containing compounds. However, most known carbonylation procedures still require noble-metal catalysts and the use of activated compounds and good nucleophiles as substrates. Herein, we developed a copper-catalyzed carbonylative transformation of cycloalkanes and amides. Imides were prepared in good yields by carbonylation of a C(sp(3) )-H bond of the cycloalkane with the amides acting as weak nucleophiles. Notably, this is the first report of copper-catalyzed carbonylative C-H activation.
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MEDLINE
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En
Ano de publicação:
2016
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Article