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Low-frequency deep brain stimulation for Parkinson's disease: Great expectation or false hope?
di Biase, Lazzaro; Fasano, Alfonso.
Afiliação
  • di Biase L; Neurology Unit, Campus Bio-Medico University of Rome, Rome, Italy.
  • Fasano A; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Mov Disord ; 31(7): 962-7, 2016 07.
Article em En | MEDLINE | ID: mdl-27173938
The long-term efficacy of subthalamic deep brain stimulation for Parkinson's disease is not always retained, and many patients lose the improvement achieved during the "second honeymoon" following surgery. Deep brain stimulation is a versatile tool, as stimulation parameters may undergo a fine-tuning depending on clinical needs. Among them, frequency is the parameter that leads to more complex scenarios because there is no generalizable relationship between its modulation and the overall clinical response, which also depends on the specific considered sign. High-frequency stimulation (>100 Hz) has shown to be effective in improving most parkinsonian signs, particularly the levodopa-responsive ones. However, its effect on axial signs (such as balance, gait, speech, or swallowing) may not be sustained, minimal, or even detrimental. For these reasons, several studies have explored the effectiveness of low-frequency stimulation (generally 60 or 80 Hz). Methods, results, and especially interpretations of these studies are quite variable. Although the use of low-frequency stimulation certainly opens new avenues in the field of deep brain stimulation, after having gathered all the available evidence in patients with subthalamic implants, our conclusion is that it might be clinically useful mainly when it lessens the detrimental effects of high-frequency stimulation. © 2016 International Parkinson and Movement Disorder Society.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estimulação Encefálica Profunda Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estimulação Encefálica Profunda Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article