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Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.
Pillinger, Genevra; Loughran, Niamh V; Piddock, Rachel E; Shafat, Manar S; Zaitseva, Lyubov; Abdul-Aziz, Amina; Lawes, Matthew J; Bowles, Kristian M; Rushworth, Stuart A.
Afiliação
  • Pillinger G; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Loughran NV; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Piddock RE; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Shafat MS; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Zaitseva L; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Abdul-Aziz A; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Lawes MJ; Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Norwich, NR4 7UY, United Kingdom.
  • Bowles KM; Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.
  • Rushworth SA; Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Norwich, NR4 7UY, United Kingdom.
Oncotarget ; 7(26): 39784-39795, 2016 Jun 28.
Article em En | MEDLINE | ID: mdl-27174919
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células da Medula Óssea / Leucemia Mieloide Aguda / Classe I de Fosfatidilinositol 3-Quinases / Classe Ib de Fosfatidilinositol 3-Quinase / Células-Tronco Mesenquimais Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células da Medula Óssea / Leucemia Mieloide Aguda / Classe I de Fosfatidilinositol 3-Quinases / Classe Ib de Fosfatidilinositol 3-Quinase / Células-Tronco Mesenquimais Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article