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Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans.
Shen, Jianwei; Serby, Michael; Surber, Bruce; Lee, Anthony J; Ma, Junli; Badri, Prajakta; Menon, Rajeev; Kavetskaia, Olga; de Morais, Sonia M; Sydor, Jens; Fischer, Volker.
Afiliação
  • Shen J; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois jian
  • Serby M; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Surber B; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Lee AJ; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Ma J; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Badri P; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Menon R; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Kavetskaia O; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • de Morais SM; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Sydor J; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
  • Fischer V; Drug Metabolism and Pharmacokinetics, Research and Development (Ji.S., M.S., A.J.L., J.M., S.M.M., V.F.), Process Chemistry (B.S.), Drug Analysis (O.K., Je.S.), and Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (P.B., R.M.), AbbVie, North Chicago, Illinois.
Drug Metab Dispos ; 44(8): 1148-57, 2016 08.
Article em En | MEDLINE | ID: mdl-27179128
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Carbamatos / Proteínas não Estruturais Virais / Hepacivirus / Anilidas Limite: Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Carbamatos / Proteínas não Estruturais Virais / Hepacivirus / Anilidas Limite: Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article