Ivy leaves dry extract EA 575® decreases LPS-induced IL-6 release from murine macrophages.
Pharmazie
; 71(3): 158-61, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-27183712
ABSTRACT
IL-6 plays a key role in the course of inflammatory processes as well as in the regulation of immune responses by the release of different cytokines. IL-6 is produced e.g. by macrophages recruited to the airways in response to a variety of inflammatory stimuli like allergens and respiratory viruses. Patients with inflammatory airway diseases therefore may benefit from therapies targeting the IL-6 pathway, e.g. reduction of the IL-6 release. Within this context, we tested the influence of the ivy leaves dry extract EA 575® on the LPS-induced release of IL-6 from murine macrophages (J774.2). One point seven µg/ml (5 µM) corticosterone served as positive control and was able to reduce LPS-induced IL-6 release by 46 ± 4%. EA 575® was tested in concentrations between 40 and 400 µg/ml. EA 575® decreased the LPS-induced IL-6 release in a dose-dependent manner and statistically significant by 25 ± 4%, 32 ± 4%, and 40 ± 7% in concentrations of 80, 160, and 400 µg/ml, respectively. The present data suggest an anti-inflammatory effect of EA 575® used in therapy of chronic- and acute inflammatory airway diseases accompanied with cough.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Lipopolissacarídeos
/
Interleucina-6
/
Hedera
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article