Selective HDAC6 inhibition prevents TNF-&#945;-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema.

Yu, Jinyan; Ma, Zhongsen; Shetty, Sreerama; Ma, Mengshi; Fu, Jian

Selective HDAC6 inhibition prevents TNF-α-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema.

Yu, Jinyan; Ma, Zhongsen; Shetty, Sreerama; Ma, Mengshi; Fu, Jian.

Afiliação

Yu J; The Second Hospital of Jilin University, Jilin, China; Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky; and.
Ma Z; The Second Hospital of Jilin University, Jilin, China;
Shetty S; Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas.
Ma M; The Second Hospital of Jilin University, Jilin, China; Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky;
Fu J; Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky; and jian.fu@uky.edu.

Am J Physiol Lung Cell Mol Physiol ; 311(1): L39-47, 2016 07 01.

Article em En | MEDLINE | ID: mdl-27190059

Assuntos

Células Endoteliais/imunologia; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/metabolismo; Ácidos Hidroxâmicos/farmacologia; Indóis/farmacologia; Edema Pulmonar/prevenção & controle; Fator de Necrose Tumoral alfa/fisiologia; Acetilação; Animais; Permeabilidade Capilar/efeitos dos fármacos; Células Cultivadas; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/imunologia; Endotélio Vascular/metabolismo; Desacetilase 6 de Histona; Humanos; Lipopolissacarídeos/farmacologia; Masculino; Camundongos Endogâmicos C57BL; Microtúbulos/metabolismo; Multimerização Proteica; Processamento de Proteína Pós-Traducional; Edema Pulmonar/imunologia; Edema Pulmonar/metabolismo; Tubulina (Proteína)/metabolismo

Palavras-chave

HDAC6; catenin; endothelial barrier; lung injury; tubulin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edema Pulmonar / Fator de Necrose Tumoral alfa / Células Endoteliais / Inibidores de Histona Desacetilases / Histona Desacetilases / Ácidos Hidroxâmicos / Indóis Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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