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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Brumatti, Gabriela; Ma, Chunyan; Lalaoui, Najoua; Nguyen, Nhu-Y; Navarro, Mario; Tanzer, Maria C; Richmond, Jennifer; Ghisi, Margherita; Salmon, Jessica M; Silke, Natasha; Pomilio, Giovanna; Glaser, Stefan P; de Valle, Elisha; Gugasyan, Raffi; Gurthridge, Mark A; Condon, Stephen M; Johnstone, Ricky W; Lock, Richard; Salvesen, Guy; Wei, Andrew; Vaux, David L; Ekert, Paul G; Silke, John.
Afiliação
  • Brumatti G; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Ma C; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Lalaoui N; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Nguyen NY; Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.
  • Navarro M; Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  • Tanzer MC; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Richmond J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2031, Australia.
  • Ghisi M; Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
  • Salmon JM; Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
  • Silke N; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Pomilio G; Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.
  • Glaser SP; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • de Valle E; Burnet Institute, Melbourne, Victoria 3004, Australia. Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
  • Gugasyan R; Burnet Institute, Melbourne, Victoria 3004, Australia. Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
  • Gurthridge MA; Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.
  • Condon SM; TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA.
  • Johnstone RW; Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
  • Lock R; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2031, Australia.
  • Salvesen G; Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  • Wei A; Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.
  • Vaux DL; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  • Ekert PG; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia. Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Victoria 3052, Australia. silke@wehi.
  • Silke J; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia. silke@wehi.edu.au paul.ekert@mcri.edu.au.
Sci Transl Med ; 8(339): 339ra69, 2016 05 18.
Article em En | MEDLINE | ID: mdl-27194727
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Pentanoicos / Dipeptídeos / Caspase 8 / Inibidores de Caspase / Indóis Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Pentanoicos / Dipeptídeos / Caspase 8 / Inibidores de Caspase / Indóis Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article