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The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression.
Ewald, Jennifer C; Kuehne, Andreas; Zamboni, Nicola; Skotheim, Jan M.
Afiliação
  • Ewald JC; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Kuehne A; Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland; PhD Program Systems Biology, Life Science Zurich Graduate School, 8057 Zurich, Switzerland.
  • Zamboni N; Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
  • Skotheim JM; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: skotheim@stanford.edu.
Mol Cell ; 62(4): 532-45, 2016 05 19.
Article em En | MEDLINE | ID: mdl-27203178
Cell division entails a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell division cycle. Here, we examine budding yeast to show that more than half of all measured metabolites change significantly through the cell division cycle. Cell cycle-dependent changes in central carbon metabolism are controlled by the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protein kinase A. At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. Thus, the cell cycle entrains carbon metabolism to fuel biosynthesis. Because the oscillation of Cdk activity is a conserved feature of the eukaryotic cell cycle, we anticipate its frequent use in dynamically regulating metabolism for efficient proliferation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Carbono / Ciclo Celular / Proteína Quinase CDC2 / Proteína Quinase CDC28 de Saccharomyces cerevisiae / Proteínas de Saccharomyces cerevisiae / Proliferação de Células / Metabolismo Energético Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Carbono / Ciclo Celular / Proteína Quinase CDC2 / Proteína Quinase CDC28 de Saccharomyces cerevisiae / Proteínas de Saccharomyces cerevisiae / Proliferação de Células / Metabolismo Energético Idioma: En Ano de publicação: 2016 Tipo de documento: Article