Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium.
Eur Radiol
; 27(2): 464-473, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27221563
ABSTRACT
OBJECTIVES:
Investigating the association between baseline cartilage volume measurements (and initial 24th month volume loss) with medial compartment Joint-Space-Loss (JSL) progression (>0.7 mm) during 24-48th months of study.METHODS:
Case and control cohorts (Biomarkers Consortium subset from the Osteoarthritis Initiative (OAI)) were defined as participants with (n=297) and without (n=303) medial JSL progression (during 24-48th months). Cartilage volume measurements (baseline and 24th month loss) were obtained at five knee plates (medial-tibial, lateral-tibial, medial-femoral, lateral-femoral and patellar), and standardized values were analysed. Multivariate logistic regression was used with adjustment for known confounders. Artificial-Neural-Network analysis was conducted by Multi-Layer-Perceptrons (MLPs) including baseline determinants, and baseline (1) and interval changes (2) in cartilage volumes.RESULTS:
Larger baseline lateral-femoral cartilage volume was predictive of medial JSL (OR 1.29 (1.01-1.64)). Greater initial 24th month lateral-femoral cartilage volume-loss (OR 0.48 (0.27-0.84)) had protective effect on medial JSL during 24-48th months of study. Baseline and interval changes in lateral-femoral cartilage volume, were the most important estimators for medial JSL progression (importance values 0.191(0.177-0.204), 0.218(0.207-0.228)) in the ANN analyses.CONCLUSIONS:
Cartilage volumes (both at baseline and their change during the initial 24 months) in the lateral femoral plate were predictive of medial JSL progression. KEY POINTS ⢠Baseline lateral femoral cartilage volume is directly associated with medial JSL progression. ⢠24-month lateral femoral cartilage loss is inversely associated with medial JSL progression. ⢠Lateral femoral cartilage volume is most important in association with medial JSL progression.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
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Osteoartrite do Joelho
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article