Physical-Chemical Properties of the Chiral Fungicide Fenamidone and Strategies for Enantioselective Crystallization.
Chirality
; 28(6): 514-20, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27225331
ABSTRACT
Thermodynamic and kinetic parameters are of prime importance for designing crystallization processes. In this article, Preferential Crystallization, as a special approach to carry out enantioselective crystallization, is described to resolve the enantiomers of the chiral fungicide fenamidone. In preliminary investigations the melting behavior and solid-liquid equilibria in the presence of solvents were quantified. The analyses revealed a stable solid phase behavior of fenamidone in the applied solvents. Based on the results obtained, a two-step crystallization route was designed and realized capable of providing highly pure enantiomers. An initial Preferential Crystallization of the racemate was performed prior to crystallizing the target enantiomer preferentially out of the enriched mother liquor. Chirality 28514-520, 2016. © 2016 Wiley Periodicals, Inc.
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MEDLINE
Assunto principal:
Cristalização
/
Estrobilurinas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article