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Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women. / Asociación entre la razón triglicéridos/colesterol HDL y ateromatosis carotídea en mujeres posmenopáusicas de mediana edad.
Masson, Walter; Siniawski, Daniel; Lobo, Martín; Molinero, Graciela; Huerín, Melina.
Afiliação
  • Masson W; Consejo de Epidemiología y Prevención Cardiovascular Dr. Mario Ciruzzi de la Sociedad Argentina de Cardiología, Buenos Aires, Argentina. Electronic address: walter.masson@hospitalitaliano.org.ar.
  • Siniawski D; Consejo de Epidemiología y Prevención Cardiovascular Dr. Mario Ciruzzi de la Sociedad Argentina de Cardiología, Buenos Aires, Argentina.
  • Lobo M; Consejo de Epidemiología y Prevención Cardiovascular Dr. Mario Ciruzzi de la Sociedad Argentina de Cardiología, Buenos Aires, Argentina.
  • Molinero G; Consejo de Epidemiología y Prevención Cardiovascular Dr. Mario Ciruzzi de la Sociedad Argentina de Cardiología, Buenos Aires, Argentina.
  • Huerín M; Consejo de Epidemiología y Prevención Cardiovascular Dr. Mario Ciruzzi de la Sociedad Argentina de Cardiología, Buenos Aires, Argentina.
Endocrinol Nutr ; 63(7): 327-32, 2016.
Article em En, Es | MEDLINE | ID: mdl-27236636
BACKGROUND AND OBJECTIVE: The triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women. The aim of this study was to explore this association. PATIENTS AND METHODS: Women (last menstrual period≥2 years) in primary prevention up to 65 years of age were recruited. Association between the triglyceride/HDL cholesterol (HDL-C) ratio and presence of carotid plaque, assessed by ultrasonography, was analyzed. ROC analysis was performed, determining the precision of this ratio to detect carotid plaque. RESULTS: A total of 332 women (age 57±5 years) were recruited. Triglyceride/HDL-C ratio was 2.35±1.6. Prevalence of carotid plaque was 29%. Women with carotid plaque had higher triglyceride/HDL-C ratios (3.33±1.96 vs. 2.1±1.2, P<.001) than women with no carotid plaque. A positive relationship was seen between quintiles of this ratio and prevalence of carotid plaque (p<.001). Regardless of other risk factors, women with higher triglyceride/HDL-C ratios were more likely to have carotid plaque (odds ratio 1.47, 95% confidence interval 1.20-1.79, P<.001). The area under the curve of the triglyceride/HDL-C ratio to detect carotid plaque was .71 (95% confidence interval .65 to .76), and the optimal cut-off point was 2.04. CONCLUSIONS: In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. A value of such ratio greater than 2 may be used for assessing cardiovascular risk in this particular group of women.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Doenças das Artérias Carótidas / Pós-Menopausa / HDL-Colesterol Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País como assunto: America do sul / Argentina Idioma: En / Es Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Doenças das Artérias Carótidas / Pós-Menopausa / HDL-Colesterol Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País como assunto: America do sul / Argentina Idioma: En / Es Ano de publicação: 2016 Tipo de documento: Article