An array of individually addressable micro-needles for mapping pH distributions.
Analyst
; 141(15): 4659-4666, 2016 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-27243147
ABSTRACT
This work describes the preparation of an array of individually addressable pH sensitive microneedles which are sensitized by electrodepositing iridium oxide. The impact of the deposition potential, storage conditions and interferents on the sensor characteristics such as slope, offset, intra- and inter-batch reproducibility is investigated. The device may be a useful tool for carrying out direct pH measurements of soft and heterogeneous samples such as tissues and organs. For example, we demonstrated that the microneedle array can be employed for real-time mapping of the cardiac pH distribution during cycles of global ischemia and reperfusion.
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MEDLINE
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article