Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).
Org Biomol Chem
; 14(25): 5922-7, 2016 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-27245438
ABSTRACT
A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat'eva reactions. Preparation of the analogous cyclohexa[c]pyridines led to the identification of a potent and more selective AS inhibitor. The structure-activity-relationship (SAR) in this new series was rationalized using binding mode models in the crystal structure of AS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Citocromo P-450 CYP11B2
/
Inibidores das Enzimas do Citocromo P-450
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article