Three new 16-membered macrolide compounds from a genetically engineered strain S. avermitilis MHJ1011.
Bioorg Med Chem Lett
; 26(14): 3376-3379, 2016 07 15.
Article
em En
| MEDLINE
| ID: mdl-27246617
ABSTRACT
Three new 16-membered macrolide compounds, 13α-O-α-l-oleandrosyl milbemycin ß3 (1), 13α-O-α-l-oleandrosyl-25-ethyl milbemycin ß3 (2), 13α-O-α-l-oleandrosyl-25-isopropyl milbemycin ß3 (3), were isolated from the genetically engineered strains Streptomyces avermitilis MHJ1011. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. Both compounds 1-3 displayed impressive acaricidal activity against larval mites with the IC50 values of 0.0327, 0.0276 and 0.0235mg/L, respectively, which are higher than those of 13α-hydroxy milbemycin ß3 and 13α-hydroxy-25-ethyl milbemycin ß3.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Engenharia Genética
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Macrolídeos
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Ácaros
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article