[The influence of the aerobic endurance training on the skeletal muscular mitochondria function and PI3K-Akt protein expression].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 32(1): 55-8, 2016 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-27255043
ABSTRACT
OBJECTIVE:
To determine the role of phosphatidylinositol 3-kinase--protein kinase B (PI3K-Akt) signaling pathway in the pro- tective effect of aerobic endurance training on the skeletal muscular mitochondria.METHODS:
Thirty-six rats were randomly divided into three groups( n = 12) control group, aerobic endurance training group and one-time exhaustive group. After the intervention, the quadriceps femoris muscle sample was obtained to detect the mitochondrial membrane potential( MMP), the activities of succinate dehydrogenase (SDH) and cy- tochrome coxidase (COX), and the protein levels of p-PI3K and p-Akt.RESULTS:
Compared with the control group, the levels of mitochondrial membrane potential, the activities of succinate dehydrogenase and cytochrome coxidase, and the protein levels of p-PI3K and p-Akt were all significantly decreased in the one-time exhaustive group (P < 0.05). However, all the above was partially reversed in the endurance training group (P < 0.05), and there was no obvious difference with the control group (P > 0.05).CONCLUSION:
Aerobic endurance training plays an important role in the protective effect on the skeletal muscular mitochondria, the mechanism may be related to activation PI3K-Akt signaling pathway.
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Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Transdução de Sinais
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Músculo Esquelético
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Fosfatidilinositol 3-Quinases
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Proteínas Proto-Oncogênicas c-akt
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Mitocôndrias
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article