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Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.
Croissant, Jonas G; Fatieiev, Yevhen; Julfakyan, Khachatur; Lu, Jie; Emwas, Abdul-Hamid; Anjum, Dalaver H; Omar, Haneen; Tamanoi, Fuyuhiko; Zink, Jeffrey I; Khashab, Niveen M.
Afiliação
  • Croissant JG; Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Fatieiev Y; Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
  • Julfakyan K; Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Lu J; Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Emwas AH; Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
  • Anjum DH; Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Omar H; Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Tamanoi F; Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
  • Zink JI; Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
  • Khashab NM; Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
Chemistry ; 22(42): 14806-14811, 2016 Oct 10.
Article em En | MEDLINE | ID: mdl-27258139
We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oxâmico / Compostos de Organossilício / Dióxido de Silício / Nanopartículas Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oxâmico / Compostos de Organossilício / Dióxido de Silício / Nanopartículas Idioma: En Ano de publicação: 2016 Tipo de documento: Article