Dangerous Entrapment for NRF2.

Gorbunova, Vera; Rezazadeh, Sarallah; Seluanov, Andrei

Gorbunova, Vera; Rezazadeh, Sarallah; Seluanov, Andrei.

Afiliação

Gorbunova V; Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA. Electronic address: vera.gorbunova@rochester.edu.
Rezazadeh S; Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA.
Seluanov A; Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA.

Cell ; 165(6): 1312-1313, 2016 Jun 02.

Article em En | MEDLINE | ID: mdl-27259142

RESUMO

Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.

Assuntos

Lamina Tipo A/metabolismo; Progéria/metabolismo; Núcleo Celular/metabolismo; Humanos; Proteínas Nucleares/metabolismo; Estresse Oxidativo; Precursores de Proteínas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Progéria / Lamina Tipo A Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Progéria / Lamina Tipo A Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article