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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.
Munoz, Diana M; Cassiani, Pamela J; Li, Li; Billy, Eric; Korn, Joshua M; Jones, Michael D; Golji, Javad; Ruddy, David A; Yu, Kristine; McAllister, Gregory; DeWeck, Antoine; Abramowski, Dorothee; Wan, Jessica; Shirley, Matthew D; Neshat, Sarah Y; Rakiec, Daniel; de Beaumont, Rosalie; Weber, Odile; Kauffmann, Audrey; McDonald, E Robert; Keen, Nicholas; Hofmann, Francesco; Sellers, William R; Schmelzle, Tobias; Stegmeier, Frank; Schlabach, Michael R.
Afiliação
  • Munoz DM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Cassiani PJ; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Li L; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Billy E; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Korn JM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Jones MD; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Golji J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Ruddy DA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Yu K; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • McAllister G; Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • DeWeck A; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Abramowski D; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Wan J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Shirley MD; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Neshat SY; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Rakiec D; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • de Beaumont R; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Weber O; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Kauffmann A; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • McDonald ER; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Keen N; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Hofmann F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Sellers WR; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Schmelzle T; Oncology Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Stegmeier F; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Schlabach MR; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. mschlabach@ksqtx.com.
Cancer Discov ; 6(8): 900-13, 2016 08.
Article em En | MEDLINE | ID: mdl-27260157
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Amplificação de Genes / Genômica / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Sistemas CRISPR-Cas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Amplificação de Genes / Genômica / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Sistemas CRISPR-Cas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article