Automated Glycan Assembly of Complex Oligosaccharides Related to Blood Group Determinants.
J Org Chem
; 81(14): 5866-77, 2016 07 15.
Article
em En
| MEDLINE
| ID: mdl-27267257
ABSTRACT
Lactotetraosyl (Lc4) and neo-lactotetraosyl (nLc4) are backbones that are common to many glycans. Using automated glycan assembly, these common core structures were constructed and elaborated to access synthetically challenging glycans of biological relevance. The incorporation of α-fucoses is demonstrated for H-type I and II; α(1,3)-galactose epitopes were prepared, and the pentasaccharide HNK-1 required incorporation of a 3-O-sulfate. In addition to preparing the target structures, essential insights were gained regarding the relationships of glycosylating agents and nucleophiles as well as the linker stability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Polissacarídeos
/
Antígenos de Grupos Sanguíneos
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Glicosilação
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article