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Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
Beck, Daniel; Zobel, Jenny; Barber, Ruth; Evans, Sian; Lezina, Larissa; Allchin, Rebecca L; Blades, Matthew; Elliott, Richard; Lord, Christopher J; Ashworth, Alan; Porter, Andrew C G; Wagner, Simon D.
Afiliação
  • Beck D; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and.
  • Zobel J; Department of Haematology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN.
  • Barber R; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and Leicester Diagnostic and Drug Development (LD3) Centre, University of Leicester, Lancaster Road, Leicester LE1 7HB.
  • Evans S; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and.
  • Lezina L; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and.
  • Allchin RL; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and.
  • Blades M; Bioinformatics and Biostatistics Analysis Support Hub (B/BASH), University of Leicester, Lancaster Road, Leicester LE1 9HN, and.
  • Elliott R; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
  • Lord CJ; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
  • Ashworth A; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
  • Porter AC; Department of Haematology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN.
  • Wagner SD; From the Department of Cancer Studies, Ernest and Helen Scott Haematology Research Institute, and sw227@le.ac.uk.
J Biol Chem ; 291(32): 16686-98, 2016 08 05.
Article em En | MEDLINE | ID: mdl-27268052
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbazóis / Linfoma Difuso de Grandes Células B / Linfoma de Burkitt / Fator de Transcrição STAT3 / Proteínas Proto-Oncogênicas c-bcl-6 / Janus Quinase 2 / Subunidade alfa de Receptor de Interleucina-10 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbazóis / Linfoma Difuso de Grandes Células B / Linfoma de Burkitt / Fator de Transcrição STAT3 / Proteínas Proto-Oncogênicas c-bcl-6 / Janus Quinase 2 / Subunidade alfa de Receptor de Interleucina-10 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article