Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.
Pediatr Blood Cancer
; 63(10): 1856-9, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27273469
ABSTRACT
Patients with common variable immunodeficiency (CVID) have a higher incidence of autoimmune disease, which may mark the disease onset; however, anemia secondary to pure red cell aplasia is an uncommon presenting feature. Here, we describe a case of CVID-like humoral immune deficiency in a child who initially presented with red cell aplasia and ultimately developed progressive bone marrow failure. Although bone marrow transplantation (BMT) has been associated with high mortality in CVID, our patient was successfully treated with a matched sibling BMT and engrafted with >98% donor chimerism and the development of normal antibody titers to diphtheria and tetanus toxoids.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
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Aplasia Pura de Série Vermelha
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Imunodeficiência de Variável Comum
Tipo de estudo:
Risk_factors_studies
Limite:
Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article