An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide.
Org Biomol Chem
; 14(26): 6297-303, 2016 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-27273742
ABSTRACT
An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.
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MEDLINE
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En
Ano de publicação:
2016
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Article