A case of essential thrombocythemia and ankylosing spondylitis treated with a combination of anagrelide, disease-modifying antirheumatic drugs, and etanercept.
Srp Arh Celok Lek
; 144(1-2): 81-4, 2016.
Article
em En
| MEDLINE
| ID: mdl-27276864
ABSTRACT
INTRODUCTION:
A high platelet count, or thrombocytosis, is either a reactive process or a result of a myeloproliferative disorder. Ankylosing spondylitis is a chronic inflammatory rheumatic disease affecting the spine and sometimes peripheral joints in which reactive mild to moderate thrombocytosis is a common finding. There have been no previously reported cases of essential thrombocythemia associated with ankylosing spondylitis. CASE OUTLINE We report a case of a 32-year-old man with human leukocyte antigen B27-positive ankylosing spondylitis and Janus kinase 2-positive essential thrombocythemia who was treated first with a combination of anagrelide and disease-modifying antirheumatic drugs and, after liver toxicity, with a combination of anagrelide and etanercept (TNF-α antagonist). Both diseases were gradually brought under control.CONCLUSION:
Our case of ankylosing spondylitis and essential thrombocythemia suggests that concomitant etanercept and anagrelide therapy is safe, as well as effective.
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Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Espondilite Anquilosante
/
Antirreumáticos
/
Etanercepte
/
Trombocitemia Essencial
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article