Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation.

Qi, Hongyi; Huang, Yongliang; Yang, Yi; Dou, Guojun; Wan, Fang; Zhang, Wenwu; Yang, Huarong; Wang, Li; Wu, Chunjie; Li, Li

Qi, Hongyi; Huang, Yongliang; Yang, Yi; Dou, Guojun; Wan, Fang; Zhang, Wenwu; Yang, Huarong; Wang, Li; Wu, Chunjie; Li, Li.

Afiliação

Qi H; College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Road, Beibei District, Chongqing, 400716, China.
Huang Y; Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Yang Y; College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Road, Beibei District, Chongqing, 400716, China.
Dou G; College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Road, Beibei District, Chongqing, 400716, China.
Wan F; Huasun Group Co., Ltd., Chengdu, 610072, Sichuan, China.
Zhang W; Huasun Group Co., Ltd., Chengdu, 610072, Sichuan, China.
Yang H; Huasun Group Co., Ltd., Chengdu, 610072, Sichuan, China.
Wang L; Huasun Group Co., Ltd., Chengdu, 610072, Sichuan, China.
Wu C; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China.
Li L; College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Road, Beibei District, Chongqing, 400716, China. lilyli029@126.com.

BMC Complement Altern Med ; 16: 174, 2016 Jun 08.

Article em En | MEDLINE | ID: mdl-27277000

Assuntos

Ginsenosídeos/farmacologia; Panax notoginseng/química; Inibidores da Agregação Plaquetária/farmacologia; Agregação Plaquetária/efeitos dos fármacos; Animais; Plaquetas/efeitos dos fármacos; Cálcio/metabolismo; Humanos; Técnicas In Vitro; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Fosforilação; Coelhos; Acidente Vascular Cerebral/prevenção & controle; Trombina/farmacologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Intracellular calcium mobilization; Panaxatriol saponin; Platelet aggregation; p-ERK2; p-p38

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Agregação Plaquetária / Ginsenosídeos / Panax notoginseng Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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