Regiocontrolled Oxidative C-C Coupling of Dienol Ethers and 1,3-Dicarbonyl Compounds.
Org Lett
; 18(13): 3182-5, 2016 07 01.
Article
em En
| MEDLINE
| ID: mdl-27280861
ABSTRACT
A strategy for synthesis of γ-alkylated enones through oxidative coupling of siloxydienes and 1,3-dicarbonyl compounds is reported. This method is an interrupted form of our formal [3 + 2] cycloaddition method reported previously. The present work excels in generating all-carbon quaternary centers via C-C bond formation at the remote γ-site which is traditionally challenging to functionalize. Stereoselectivity and functional group tolerance are examined in complex systems. Double alkylation reactions are also described.
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MEDLINE
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En
Ano de publicação:
2016
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Article