Cytomegalovirus-negative kidney transplant recipients are at an increased risk for malignancy after kidney transplantation.
Clin Transplant
; 30(9): 980-5, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27286324
ABSTRACT
BACKGROUND:
The effect of cytomegalovirus (CMV) serology status on malignancy risk in kidney transplanted patients is not clear yet.METHODS:
In a nested case-control study, CMV serology status was compared between patients with a malignancy and 21 matched control patients without a malignancy. In a cohort study, the hazard of malignancy was compared between patients that were CMV-negative but had a CMV-positive donor and other patients, using Cox analysis.RESULTS:
Fifty-two of 599 patients transplanted in our center between 2001 and 2014 developed a malignancy. Nine (17.3%) of the 52 patients that developed cancer were CMV-negative but had a-CMV-positive donor compared with 6 (5.8%) of the 104 matched control patients (odd ratio 3.42, 95% confidence interval [CI] 1.15-10.2, P=.021). By univariate Cox model, there was a trend toward increased cancer risk in CMV-negative patients with a positive donor (hazard ratio [HR] 1.95, 95% CI 0.95-4.0, P=.07), but after adjusting for multiple covariates, CMV-negative status was significantly associated with increased risk of cancer (HR 2.55, 95% CI 1.23-5.26; P=.012).CONCLUSIONS:
CMV-negative patients that had a CMV-positive donor were found to have a higher risk of malignancy after kidney transplantation.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Anti-Hepatite
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Transplante de Rim
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Infecções por Citomegalovirus
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Citomegalovirus
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Transplantados
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Rejeição de Enxerto
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Neoplasias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article