Modulating Cholesterol Homeostasis to Build a Better T Cell.

Kidani, Yoko; Bensinger, Steven J

Kidani, Yoko; Bensinger, Steven J.

Afiliação

Kidani Y; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bensinger SJ; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sbensinger@mednet.ucla.edu.

Cell Metab ; 23(6): 963-964, 2016 06 14.

Article em En | MEDLINE | ID: mdl-27304495

ABSTRACT

ABSTRACT

There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.

Assuntos

Linfócitos T CD8-Positivos/metabolismo; Colesterol/metabolismo; Homeostase; Acetil-CoA C-Acetiltransferase/metabolismo; Animais; Ativação Linfocitária/imunologia; Camundongos; Modelos Biológicos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colesterol / Linfócitos T CD8-Positivos / Homeostase Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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