To die, or not to die: E2F1 never decides by itself during serum starvation.
Mol Cell Oncol
; 2(2): e981447, 2015.
Article
em En
| MEDLINE
| ID: mdl-27308445
ABSTRACT
The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.
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MEDLINE
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En
Ano de publicação:
2015
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Article