TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
Mol Cell Oncol
; 2(3): e980134, 2015.
Article
em En
| MEDLINE
| ID: mdl-27308456
ABSTRACT
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
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Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article