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Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.
Parkhitko, Andrey A; Binari, Richard; Zhang, Nannan; Asara, John M; Demontis, Fabio; Perrimon, Norbert.
Afiliação
  • Parkhitko AA; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA;
  • Binari R; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA;
  • Zhang N; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University, Beijing 100084, China;
  • Asara JM; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA;
  • Demontis F; Department of Developmental Neurobiology, Division of Developmental Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
  • Perrimon N; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA;
Genes Dev ; 30(12): 1409-22, 2016 06 15.
Article em En | MEDLINE | ID: mdl-27313316
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Regulação para Baixo / Proteínas de Drosophila / Peptídeos e Proteínas de Sinalização Intracelular / Drosophila melanogaster / Longevidade Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Regulação para Baixo / Proteínas de Drosophila / Peptídeos e Proteínas de Sinalização Intracelular / Drosophila melanogaster / Longevidade Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article