Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2.

Jain, Abhinav K; Barton, Michelle C

Jain, Abhinav K; Barton, Michelle C.

Afiliação

Jain AK; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Stem Cell & Development Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Barton MC; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Stem Cell & Development Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. Electronic address: mbarton@mdanderson.

Mol Cell ; 62(6): 805-807, 2016 06 16.

Article em En | MEDLINE | ID: mdl-27315554

ABSTRACT

ABSTRACT

Evidence mounts, via two studies published in Molecular Cell (Riscal et al., 2016; Wienken et al., 2016), that chromatin-bound MDM2 impacts pluripotency and metabolism to promote survival and proliferation of cancer cells, independently of p53 degradation.

Assuntos

Cromatina; Proteínas Proto-Oncogênicas c-mdm2/genética; Linhagem Celular Tumoral; Regulação da Expressão Gênica; Humanos; Proteínas Nucleares; Proteínas Proto-Oncogênicas/genética; Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatina / Proteínas Proto-Oncogênicas c-mdm2 Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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