Positive correlation between serum IGF-1 and HDL-C in type 2 diabetes mellitus.
Diabetes Res Clin Pract
; 118: 44-9, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27322526
ABSTRACT
OBJECTIVE:
Dyslipidemia and low levels of high density lipoprotein cholesterol (HDL-C) can increase the risk of atherosclerosis development in people with type 2 diabetes mellitus (T2DM). This study aimed to investigate the correlation between serum HDL-C and insulin-like growth factor-1 (IGF-1), which are crucially involved inT2DM.METHODS:
Serum concentrations of IGF-1, total cholesterol, triglyceride, low density lipoprotein cholesterol, and HDL-C were measured in 498 participants with T2DM without any lipid-modifying medicine prior to study. Participants were divided into three groups according to the 25th and 75th percentile of IGF-1 levels low IGF-1 group (G1), middle IGF-1 group (G2), and high IGF-1 group (G3), respectively. Serum levels of HDL-C were compared among the three groups.RESULTS:
G1 presented a higher body mass index and higher fasting plasma insulin (FINS) than G2 (P<0.05), yet a lower HDL-C than G2 (P<0.05). Moreover, HDL-C, postprandial blood glucose, FINS, postprandial plasma insulin (PINS), hip circumference ratio, glycated hemoglobin A1c were significantly lower in G3 than in G2 (P<0.05). After adjusting for age and gender, serum levels of IGF-1 were negatively correlated with age, duration of disease, waist circumference, FINS, PINS, and insulin resistance, but positively correlated with HDL-C. Each increase of 2.71ng/dl in IGF-I concentration was associated with an increase of 1.34mg/dl in HDL level.CONCLUSIONS:
IGF-1 serum level in people with T2DM is correlated positively with HDL-C.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Glicemia
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Resistência à Insulina
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Fator de Crescimento Insulin-Like I
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Diabetes Mellitus Tipo 2
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Metabolismo dos Lipídeos
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HDL-Colesterol
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article