Regioselective routes to orthogonally-substituted aromatic MIDA boronates.
Org Biomol Chem
; 14(28): 6751-6, 2016 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-27327563
ABSTRACT
A series of tetrasubstituted aromatics has been synthesized, many of which are based on elaborated N-methyliminodiacetic acid (MIDA)-boronates. A sequence employing nitration, bromination, stepwise Suzuki-Miyaura (SM) coupling with a boronic acid, then base-mediated unmasking of the boronic acid from the MIDA-boronate and a second SM-coupling has led to our desired, mainly 1,2,4,5-substituted tetrasubstituted aromatic targets.
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MEDLINE
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En
Ano de publicação:
2016
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Article