Local anesthetic lidocaine delivery system: chitosan and hyaluronic acid-modified layer-by-layer lipid nanoparticles.
Drug Deliv
; 23(9): 3529-3537, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27340888
ABSTRACT
CONTEXT Transdermal local anesthesia is one of the most applied strategies to avoid systemic adverse effects; there is an appealing need for a prolonged local anesthetic that would provide better bioavailability and longer pain relief with a single administration. OBJECTIVE:
Layer-by-layer (LBL) technique was used in this study to explore a nanosized drug delivery system for local anesthetic therapy. MATERIALS ANDMETHODS:
LBL-coated lidocaine-loaded nanostructured lipid nanoparticles (LBL-LA/NLCs) were prepared and characterized in terms of particle size (PS), zeta potential, drug encapsulation efficiency (EE), in vitro skin permeation and in vivo local anesthetic studies.RESULTS:
Evaluation of the in vitro skin permeation and in vivo anesthesia effect illustrated that LBL-LA/NLCs can enhance and prolong the anesthetic effect of LA. DISCUSSION ANDCONCLUSION:
LBL-LA/NLCs could function as a promising drug delivery strategy for overcoming the barrier function of the skin and could deliver anesthetic through the skin with sustained release behavior for local anesthetic therapy.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Quitosana
/
Nanopartículas
/
Ácido Hialurônico
/
Anestésicos Locais
/
Lidocaína
/
Lipídeos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article