Antimalarial Phenanthroindolizine Alkaloids from Ficus septica.
Chem Pharm Bull (Tokyo)
; 64(7): 957-60, 2016.
Article
em En
| MEDLINE
| ID: mdl-27373653
ABSTRACT
During the screening of antimalarial substances, MeOH extract from the twigs of Ficus septica was shown to have potent antimalarial activity. Bioassay-guided fractionation of a methanol extract of the twigs of F. septica led to the isolation of a new seco-phenanthroindolizine alkaloid and three known phenanthroindolizine alkaloids. Their structures were elucidated on the basis of NMR analysis. All isolated compounds were tested against Plasmodium falciparum. Compounds 2-4 displayed antimalarial activity against the 3D7 strain of P. falciparum with IC50 values 0.028-0.42 µM, whereas a new compound 1 exhibited a moderate antimalarial activity.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Ficus
/
Alcaloides
/
Antimaláricos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article