Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.

Guzmán, Esther A; Xu, Qunli; Pitts, Tara P; Mitsuhashi, Kaoru Ogawa; Baker, Cheryl; Linley, Patricia A; Oestreicher, Judy; Tendyke, Karen; Winder, Priscilla L; Suh, Edward M; Wright, Amy E

Guzmán, Esther A; Xu, Qunli; Pitts, Tara P; Mitsuhashi, Kaoru Ogawa; Baker, Cheryl; Linley, Patricia A; Oestreicher, Judy; Tendyke, Karen; Winder, Priscilla L; Suh, Edward M; Wright, Amy E.

Afiliação

Guzmán EA; Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce, FL, 34946.
Xu Q; Eisai Research Institute of Boston Inc, Andover, MA, 01810-2441.
Pitts TP; Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce, FL, 34946.
Mitsuhashi KO; Eisai Co, Ltd, Tsukuba-Shi, Ibaraki, 300-2635, Japan.
Baker C; Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL, 32827.
Linley PA; Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce, FL, 34946.
Oestreicher J; Eisai Research Institute of Boston Inc, Andover, MA, 01810-2441.
Tendyke K; Eisai Research Institute of Boston Inc, Andover, MA, 01810-2441.
Winder PL; Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce, FL, 34946.
Suh EM; Eisai Research Institute of Boston Inc, Andover, MA, 01810-2441.
Wright AE; Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce, FL, 34946.

Int J Cancer ; 139(9): 2116-26, 2016 11 01.

Article em En | MEDLINE | ID: mdl-27376928

Assuntos

Antineoplásicos/administração & dosagem; Macrolídeos/administração & dosagem; Microtúbulos/efeitos dos fármacos; Neoplasias Pancreáticas/tratamento farmacológico; Moduladores de Tubulina/administração & dosagem; Animais; Antineoplásicos/farmacologia; Apoptose; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Células HeLa; Humanos; Macrolídeos/farmacologia; Camundongos; Proteínas Associadas aos Microtúbulos/metabolismo; Metástase Neoplásica; Neoplasias Pancreáticas/metabolismo; Moduladores de Tubulina/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

marine natural products; microtubule associated proteins; pancreatic cancer; tubulin dynamics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Macrolídeos / Moduladores de Tubulina / Microtúbulos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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