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Comparative Evaluation of ß-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules.
Isaeva, A V; Zima, A P; Saprina, T V; Kasoyan, K T; Popov, O S; Brynova, O V; Berezkina, I S; Vasil'eva, O A; Ryazantseva, N V; Shabalova, I P; Litvinova, L S; Pak, Yu D; Novitskii, V V.
Afiliação
  • Isaeva AV; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. seneann@mail.ru.
  • Zima AP; Tomsk Research Institute of Oncology, Tomsk, Russia. seneann@mail.ru.
  • Saprina TV; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Kasoyan KT; I. Kant Baltic Federal University, Kaliningrad, Russia.
  • Popov OS; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Brynova OV; Russian Medical Academy of Postgraduate Education, Moscow, Russia.
  • Berezkina IS; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Vasil'eva OA; Moscow Municipal Oncological Hospital No. 62, Moscow, Russia.
  • Ryazantseva NV; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Shabalova IP; Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Litvinova LS; V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
  • Pak YD; Siberian Federal University, Krasnoyarsk, Russia.
  • Novitskii VV; Russian Medical Academy of Postgraduate Education, Moscow, Russia.
Bull Exp Biol Med ; 161(2): 288-91, 2016 Jun.
Article em En | MEDLINE | ID: mdl-27383156
ABSTRACT
We compared the results of gene molecular and immunocytochemical studies of ß-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/ß-catenin complex leading to switching from adhesion function of ß-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-ß-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Carcinoma Papilar / Biomarcadores Tumorais / Caderinas / Beta Catenina Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Carcinoma Papilar / Biomarcadores Tumorais / Caderinas / Beta Catenina Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article